MovDisordV3, Main, Exploration, bibRecord, 004109

Effect of ethanol on the central oscillator in essential tremor

Identifieur interne : 004109 ( Main/Exploration ); précédent : 004108; suivant : 004110

Effect of ethanol on the central oscillator in essential tremor

Auteurs : Kirsten E. Zeuner [États-Unis] ; Fiona M. Molloy [États-Unis] ; Richard O. Shoge [États-Unis] ; Susanne R. Goldstein [États-Unis] ; Robert Wesley [États-Unis] ; Mark Hallett [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2003-11.

RBID : ISTEX:34DD7C234799ED458B02C98BACBD145ECA714EF1

Descripteurs français

Pascal (Inist)
- Accélérométrie, Benzodiazépine dérivé, Diazépam, Essentiel, Ethanol, Exploration, Homme, Oscillateur, Tremblement.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Accelerometry, Benzodiazepine derivatives, Biological Clocks (drug effects), Central Nervous System Stimulants (therapeutic use), Cross-Over Studies, Diazepam, Double-Blind Method, Electromyography, Essential, Essential Tremor (diagnosis), Essential Tremor (drug therapy), Essential Tremor (epidemiology), Ethanol, Ethanol (therapeutic use), Exploration, Female, Human, Humans, Male, Middle Aged, Oscillator, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Questionnaires, Tremor, accelerometry, central oscillator, ethanol in essential tremor, mechanical (reflex) component.
MESH :
- chemical , therapeutic use : Central Nervous System Stimulants, Ethanol.
- diagnosis : Essential Tremor, Parkinson Disease.
- drug effects : Biological Clocks.
- drug therapy : Essential Tremor, Parkinson Disease.
- epidemiology : Essential Tremor, Parkinson Disease.
- Cross-Over Studies, Double-Blind Method, Electromyography, Female, Humans, Male, Middle Aged, Questionnaires.

Abstract

We investigated the effects of ethanol and diazepam on the central, mechanical, and mechanical reflex components of tremor in patients with essential tremor (ET). A double‐blind crossover study (ethanol or diazepam) was conducted on 2 separate days. Dose of ethanol or diazepam was calculated in each individual according to height, weight, and age in 10 patients with ET. The postural tremor amplitude at the wrist was recorded using a three‐dimensional accelerometer placed on the dorsum of the hand. Electromyogram (EMG) was recorded with surface electrodes placed on the forearm extensors and flexors. To separate central and mechanical (reflex) components, a 500‐g weight was placed on the dorsum of the hand during a second tremor measurement. Tremor recordings were done at baseline and 30, 60, 90, and 120 minutes after drug ingestion. Ethanol and diazepam blood levels were measured at baseline and after 20, 40, 80, and 120 minutes. Blood ethanol and diazepam levels were highest after 40 and 80 minutes. The amplitude of the central component 60 minutes after ingestion of ethanol was decreased significantly (P = 0.029) compared with diazepam. Our findings suggest that the improvement in tremor after ethanol ingestion was due, at least in part, to an effect on a central oscillator. © 2003 Movement Disorder Society

Url:

https://api.istex.fr/document/34DD7C234799ED458B02C98BACBD145ECA714EF1/fulltext/pdf

DOI: 10.1002/mds.10553

Affiliations:

Le document en format XML

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<term>Cross-Over Studies</term>
<term>Diazepam</term>
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<term>Essential Tremor (diagnosis)</term>
<term>Essential Tremor (drug therapy)</term>
<term>Essential Tremor (epidemiology)</term>
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<term>Middle Aged</term>
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<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Questionnaires</term>
<term>Tremor</term>
<term>accelerometry</term>
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<front><div type="abstract" xml:lang="en">We investigated the effects of ethanol and diazepam on the central, mechanical, and mechanical reflex components of tremor in patients with essential tremor (ET). A double‐blind crossover study (ethanol or diazepam) was conducted on 2 separate days. Dose of ethanol or diazepam was calculated in each individual according to height, weight, and age in 10 patients with ET. The postural tremor amplitude at the wrist was recorded using a three‐dimensional accelerometer placed on the dorsum of the hand. Electromyogram (EMG) was recorded with surface electrodes placed on the forearm extensors and flexors. To separate central and mechanical (reflex) components, a 500‐g weight was placed on the dorsum of the hand during a second tremor measurement. Tremor recordings were done at baseline and 30, 60, 90, and 120 minutes after drug ingestion. Ethanol and diazepam blood levels were measured at baseline and after 20, 40, 80, and 120 minutes. Blood ethanol and diazepam levels were highest after 40 and 80 minutes. The amplitude of the central component 60 minutes after ingestion of ethanol was decreased significantly (P = 0.029) compared with diazepam. Our findings suggest that the improvement in tremor after ethanol ingestion was due, at least in part, to an effect on a central oscillator. © 2003 Movement Disorder Society</div>
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Movement Disorders (revue)

Effect of ethanol on the central oscillator in essential tremor

Effect of ethanol on the central oscillator in essential tremor

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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